Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress

Beyond its presence in stable microtubules, tubulin acetylation can be boosted after UV exposure or after nutrient deprivation, but the mechanisms of microtubule hyperacetylation are still unknown. In this study, we show that this hyperacetylation is a common response to several cellular stresses th...

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Detalhes bibliográficos
Main Authors: Mackeh, Rafah, Lorin, Séverine, Ratier, Ameetha, Mejdoubi-Charef, Najet, Baillet, Anita, Bruneel, Arnaud, Hamaï, Ahmed, Codogno, Patrice, Poüs, Christian, Perdiz, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002089/
https://ncbi.nlm.nih.gov/pubmed/24619423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507400
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