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Overexpression of the Na(+)/K(+) ATPase α2 but not α1 Isoform Attenuates Pathological Cardiac Hypertrophy and Remodeling
RATIONALE: The Na(+)/K(+) ATPase (NKA) directly regulates intracellular Na(+) levels, which in turn indirectly regulates Ca(2+) levels by proximally controlling flux through the Na(+)/Ca(2+) exchanger (NCX1). Elevated Na(+) levels have been reported during heart failure, which permits some degree of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001807/ https://ncbi.nlm.nih.gov/pubmed/24218169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.302293 |
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