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Evolutionary imprint of activation: The design principles of VSDs
Voltage-sensor domains (VSDs) are modular biomolecular machines that transduce electrical signals in cells through a highly conserved activation mechanism. Here, we investigate sequence–function relationships in VSDs with approaches from information theory and probabilistic modeling. Specifically, w...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001776/ https://ncbi.nlm.nih.gov/pubmed/24470486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311103 |
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