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Evolutionary imprint of activation: The design principles of VSDs

Voltage-sensor domains (VSDs) are modular biomolecular machines that transduce electrical signals in cells through a highly conserved activation mechanism. Here, we investigate sequence–function relationships in VSDs with approaches from information theory and probabilistic modeling. Specifically, w...

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Autors principals: Palovcak, Eugene, Delemotte, Lucie, Klein, Michael L., Carnevale, Vincenzo
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001776/
https://ncbi.nlm.nih.gov/pubmed/24470486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311103
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