Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed-Pharmacogenomics

Though aspirin is a well-established antiplatelet agent, the mechanisms of aspirin resistance remain poorly understood. Metabolomics allows for measurement of hundreds of small molecules in biological samples enabling detailed mapping of pathways involved in drug response. We defined the metabolic s...

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Main Authors: Yerges-Armstrong, Laura M., Ellero-Simatos, Sandrine, Georgiades, Anastasia, Zhu, Hongjie, Lewis, Joshua, Horenstein, Richard B., Beitelshees, Amber L., Dane, Adrie, Reijmers, Theo, Hankemeier, Thomas, Fiehn, Oliver, Shuldiner, Alan R., Kaddurah-Daouk, Rima
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001726/
https://ncbi.nlm.nih.gov/pubmed/23839601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.119
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