Anticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa

Oplopantriol-A (OPT) is a natural polyyne from Oplopanax horridus. We show here that OPT preferentially kills cancer cells and inhibits tumor growth. We demonstrate that OPT-induced cancer cell death is mediated by excessive endoplasmic reticulum (ER) stress. Decreasing the level of ER stress either...

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Detalhes bibliográficos
Main Authors: Jin, H R, Liao, Y, Li, X, Zhang, Z, Zhao, J, Wang, C-Z, Huang, W-H, Li, S-P, Yuan, C-S, Du, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001317/
https://ncbi.nlm.nih.gov/pubmed/24763047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.169
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