Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling

Missense mutations in the p53 tumor suppressor inactivate its anti-proliferative properties but can also promote metastasis through a gain-of-function activity. We show that sustained expression of mutant p53 is required to maintain the pro-metastatic phenotype of a murine model of pancreatic cancer...

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Detalhes bibliográficos
Main Authors: Weissmueller, Susann, Manchado, Eusebio, Saborowski, Michael, Morris, John P., Wagenblast, Elvin, Davis, Carrie A., Moon, Sung-Hwan, Pfister, Neil T., Tschaharganeh, Darjus F., Kitzing, Thomas, Aust, Daniela, Markert, Elke K., Wu, Jianmin, Grimmond, Sean M., Pilarsky, Christian, Prives, Carol, Biankin, Andrew V., Lowe, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001090/
https://ncbi.nlm.nih.gov/pubmed/24725405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.066
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