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Total Synthesis of the Lipid Mediator PD1(n-3 DPA): Configurational Assignments and Anti-inflammatory and Pro-resolving Actions
[Image: see text] The polyunsaturated lipid mediator PD1(n-3 DPA) (5) was recently isolated from self-resolving inflammatory exudates of 5 and human macrophages. Herein, the first total synthesis of PD1(n-3 DPA) (5) is reported in 10 steps and 9% overall yield. These efforts, together with NMR data...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society and American
Society of Pharmacognosy
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4000582/ https://ncbi.nlm.nih.gov/pubmed/24576195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np4009865 |
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