Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation

Nuclear localization of non-phosphorylated, active β-catenin is a measure of Wnt pathway activation and is associated with adverse outcome in patients with acute myeloid leukemia (AML). While genetic alterations of the Wnt pathway are infrequent in AML, inhibitors of this pathway are silenced by pro...

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Autores principales: GRIFFITHS, ELIZABETH A., GORE, STEVEN D., HOOKER, CRAIG M., MCDEVITT, MICHAEL A., KARP, JUDITH E., SMITH, B. DOUGLAS, MOHAMMAD, HELAI P., YE, YING, HERMAN, JAMES G., CARRAWAY, HETTY E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000011/
https://ncbi.nlm.nih.gov/pubmed/20795789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2010.496505
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