Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and choosing therapies based on assumptions that DIPGs...

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Hlavní autoři: Buczkowicz, Pawel, Hoeman, Christine, Rakopoulos, Patricia, Pajovic, Sanja, Letourneau, Louis, Dzamba, Misko, Morrison, Andrew, Lewis, Peter, Bouffet, Eric, Bartels, Ute, Zuccaro, Jennifer, Agnihotri, Sameer, Ryall, Scott, Barszczyk, Mark, Chornenkyy, Yevgen, Bourgey, Mathieu, Bourque, Guillaume, Montpetit, Alexandre, Cordero, Francisco, Castelo-Branco, Pedro, Mangerel, Joshua, Tabori, Uri, Ho, King Ching, Huang, Annie, Taylor, Kathryn R., Mackay, Alan, Bendel, Anne E, Nazarian, Javad, Fangusaro, Jason R, Karajannis, Matthias A., Zagzag, David, Foreman, Nicholas K., Donson, Andrew, Hegert, Julia V., Smith, Amy, Chan, Jennifer, Lafay-Cousin, Lucy, Dunn, Sandra, Hukin, Juliette, Dunham, Chris, Scheinemann, Katrin, Michaud, Jean, Zelcer, Shayna, Ramsay, David, Cain, Jason, Brennan, Cameron, Souweidane, Mark M., Jones, Chris, Allis, C. David, Brudno, Michael, Becher, Oren, Hawkins, Cynthia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997489/
https://ncbi.nlm.nih.gov/pubmed/24705254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2936
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