Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and choosing therapies based on assumptions that DIPGs...

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Main Authors: Buczkowicz, Pawel, Hoeman, Christine, Rakopoulos, Patricia, Pajovic, Sanja, Letourneau, Louis, Dzamba, Misko, Morrison, Andrew, Lewis, Peter, Bouffet, Eric, Bartels, Ute, Zuccaro, Jennifer, Agnihotri, Sameer, Ryall, Scott, Barszczyk, Mark, Chornenkyy, Yevgen, Bourgey, Mathieu, Bourque, Guillaume, Montpetit, Alexandre, Cordero, Francisco, Castelo-Branco, Pedro, Mangerel, Joshua, Tabori, Uri, Ho, King Ching, Huang, Annie, Taylor, Kathryn R., Mackay, Alan, Bendel, Anne E, Nazarian, Javad, Fangusaro, Jason R, Karajannis, Matthias A., Zagzag, David, Foreman, Nicholas K., Donson, Andrew, Hegert, Julia V., Smith, Amy, Chan, Jennifer, Lafay-Cousin, Lucy, Dunn, Sandra, Hukin, Juliette, Dunham, Chris, Scheinemann, Katrin, Michaud, Jean, Zelcer, Shayna, Ramsay, David, Cain, Jason, Brennan, Cameron, Souweidane, Mark M., Jones, Chris, Allis, C. David, Brudno, Michael, Becher, Oren, Hawkins, Cynthia
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997489/
https://ncbi.nlm.nih.gov/pubmed/24705254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2936
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