Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation, and release of cyclic guanosine-3′,5′-monophosphate (cGMP). Evidence that the visceral analgesic e...

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Detalhes bibliográficos
Main Authors: Hannig, Gerhard, Tchernychev, Boris, Kurtz, Caroline B., Bryant, Alexander P., Currie, Mark G., Silos-Santiago, Inmaculada
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997039/
https://ncbi.nlm.nih.gov/pubmed/24795564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00031
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