Phosphorylated 4E-BP1 is Associated with Poor Survival in Melanoma

PURPOSE: Both the PI3K/AKT and RAS/MAPK signal transduction pathways mediate 4E-BP1 phosphorylation, releasing 4E-BP1 from the mRNA cap and permitting translation initiation. Given the prevalence of PTEN and B-RAF mutations in melanoma, we first examined translation initiation, as measured by phosph...

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Hauptverfasser: O’Reilly, Kathryn E., Warycha, Melanie, Davies, Michael A., Rodrik, Vanessa, Zhou, Xi K., Yee, Herman, Polsky, David, Pavlick, Anna C., Rosen, Neal, Bhardwaj, Nina, Mills, Gordon, Osman, Iman
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3995540/
https://ncbi.nlm.nih.gov/pubmed/19336517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2336
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