Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy

BACKGROUND: Matrix metalloproteinase-23 (MMP-23) can block the voltage-gated potassium channel Kv1.3, whose function is important for sustained Ca(2+) signaling during T cell activation. MMP-23 may also alter T cell activity and phenotype through cleavage of proteins affecting cytokine and chemokine...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Moogk, Duane, da Silva, Ines Pires, Ma, Michelle W, Friedman, Erica B, de Miera, Eleazar Vega-Saenz, Darvishian, Farbod, Scanlon, Patrick, Perez-Garcia, Arianne, Pavlick, Anna C, Bhardwaj, Nina, Christos, Paul J, Osman, Iman, Krogsgaard, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272770/
https://ncbi.nlm.nih.gov/pubmed/25491880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0342-7
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