c9,t11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway

Oxidative stress, hepatic steatosis, and mitochondrial dysfunction are key pathophysiological features of nonalcoholic fatty liver disease. A conjugated linoleic acid (CLA) mixture of cis9,trans11 (9,11-CLA) and trans10,cis12 (10,12-CLA) isomers enhanced the antioxidant/detoxifying mechanism via the...

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Autori principali: Mollica, Maria Pina, Trinchese, Giovanna, Cavaliere, Gina, De Filippo, Chiara, Cocca, Ennio, Gaita, Marcello, Della-Gatta, Antonio, Marano, Angela, Mazzarella, Giuseppe, Bergamo, Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2014
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3995462/
https://ncbi.nlm.nih.gov/pubmed/24634500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M044032
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