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PI3K and Cancer: Lessons, Challenges and Opportunities
The central role of phosphoinositide 3-kinase (PI3K) activation in tumor cell biology has prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and mTOR in cancer. However, emerging clinical data show limited single agent activity of PI3K/AKT/mTOR inhibitors at tolerated do...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3994981/ https://ncbi.nlm.nih.gov/pubmed/24481312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd4204 |
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