Mechanism of Action and Capsid-Stabilizing Properties of VHHs with an In Vitro Antipolioviral Activity

Previously, we reported on the in vitro antiviral activity of single-domain antibody fragments (VHHs) directed against poliovirus type 1. Five VHHs were found to neutralize poliovirus type 1 in an in vitro setting and showed 50% effective concentrations (EC(50)s) in the nanomolar range. In the prese...

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Bibliografiske detaljer
Main Authors: Schotte, Lise, Strauss, Mike, Thys, Bert, Halewyck, Hadewych, Filman, David J., Bostina, Mihnea, Hogle, James M., Rombaut, Bart
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993733/
https://ncbi.nlm.nih.gov/pubmed/24501405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03402-13
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