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Genetic Characterization of the Role of the Cip/Kip Family of Proteins as Cyclin-Dependent Kinase Inhibitors and Assembly Factors

The Cip/Kip family, namely, p21(Cip1), p27(Kip1), and p57(Kip2), are stoichiometric cyclin-dependent kinase inhibitors (CKIs). Paradoxically, they have been proposed to also act as positive regulators of Cdk4/6-cyclin D by stabilizing these heterodimers. Loss of p21(Cip1) and p27(Kip1) reduces Cdk4/...

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מידע ביבליוגרפי
Main Authors: Cerqueira, Antonio, Martín, Alberto, Symonds, Catherine E., Odajima, Junko, Dubus, Pierre, Barbacid, Mariano, Santamaría, David
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993583/
https://ncbi.nlm.nih.gov/pubmed/24515438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01163-13
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