L-Plastin Is Essential for Alveolar Macrophage Production and Control of Pulmonary Pneumococcal Infection

We report that mice deficient for the hematopoietic-specific, actin-bundling protein L-plastin (LPL) succumb rapidly to intratracheal pneumococcal infection. The increased susceptibility of LPL(−/−) mice to pulmonary pneumococcal challenge correlated with reduced numbers of alveolar macrophages, con...

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Detalhes bibliográficos
Main Authors: Deady, Lauren E., Todd, Elizabeth M., Davis, Chris G., Zhou, Julie Y., Topcagic, Nermina, Edelson, Brian T., Ferkol, Thomas W., Cooper, Megan A., Muenzer, Jared T., Morley, Sharon Celeste
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993441/
https://ncbi.nlm.nih.gov/pubmed/24595139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01199-13
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