NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy

The need for new antibiotics that address serious Gram-negative infections is well recognized. Our efforts with a series of novel bacterial type II topoisomerase inhibitors (NBTIs) led to the discovery of NBTI 5463, an agent with improved activity over other NBTIs against Gram-negative bacteria, in...

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Detalhes bibliográficos
Main Authors: Dougherty, Thomas J., Nayar, Asha, Newman, Joseph V., Hopkins, Sussie, Stone, Gregory G., Johnstone, Michele, Shapiro, Adam B., Cronin, Mark, Reck, Folkert, Ehmann, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993248/
https://ncbi.nlm.nih.gov/pubmed/24566174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02778-13
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