Improvement of the Pharmacokinetics and In Vivo Antibacterial Efficacy of a Novel Type IIa Topoisomerase Inhibitor by Formulation in Liposomes

Several useful properties of liposome-based formulations of various existing antibacterial drugs have been reported. These properties include lower MICs, improved pharmacokinetics, lower toxicity, selective distribution to infected tissues, and enhanced in vivo efficacy. Here we report in vivo studi...

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Bibliografiska uppgifter
Huvudupphovsmän: Shapiro, Adam B., Newman, Joseph, Goteti, Kosalaram, Beaudoin, Marie-Eve, Harrison, Rane, Hopkins, Sussie, Agrawal, Nikunj, Rivin, Olga
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2013
Ämnen:
Experimental Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811447/
https://ncbi.nlm.nih.gov/pubmed/23877679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00163-13
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