Improvement of the Pharmacokinetics and In Vivo Antibacterial Efficacy of a Novel Type IIa Topoisomerase Inhibitor by Formulation in Liposomes

Several useful properties of liposome-based formulations of various existing antibacterial drugs have been reported. These properties include lower MICs, improved pharmacokinetics, lower toxicity, selective distribution to infected tissues, and enhanced in vivo efficacy. Here we report in vivo studi...

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Detalhes bibliográficos
Main Authors: Shapiro, Adam B., Newman, Joseph, Goteti, Kosalaram, Beaudoin, Marie-Eve, Harrison, Rane, Hopkins, Sussie, Agrawal, Nikunj, Rivin, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811447/
https://ncbi.nlm.nih.gov/pubmed/23877679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00163-13
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