Increased SK2 channel-mediated negative feedback on NMDAR impairs synaptic plasticity following context-dependent sensitization to morphine

BACKGROUND: Hippocampal long term potentiation (LTP) is impaired following repeated morphine administration paired with a novel context. This procedure produces locomotor sensitization that can be abolished by blocking Ca(2+)-permeable 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid rece...

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Bibliographic Details
Main Authors: Fakira, Amanda K., Portugal, George S., Carusillo, Brianna, Melyan, Zare, Morón, Jose A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992971/
https://ncbi.nlm.nih.gov/pubmed/23735878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.04.026
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