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Increased SK2 channel-mediated negative feedback on NMDAR impairs synaptic plasticity following context-dependent sensitization to morphine
BACKGROUND: Hippocampal long term potentiation (LTP) is impaired following repeated morphine administration paired with a novel context. This procedure produces locomotor sensitization that can be abolished by blocking Ca(2+)-permeable 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid rece...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3992971/ https://ncbi.nlm.nih.gov/pubmed/23735878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.04.026 |
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