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In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model
N-methyl-D-aspartate receptor (NMDAR) antagonists have been shown to reduce mechanical hypersensitivity in animal models of inflammatory pain. However, their clinical use is associated with significant dose-limiting side effects. Small conductance Ca(2+)-activated K(+) channels (SK) have been shown...
Tallennettuna:
| Julkaisussa: | Pain |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4428572/ https://ncbi.nlm.nih.gov/pubmed/25734988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000124 |
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