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Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin
Proline switches, controlled by cis–trans isomerization, have emerged as a particularly effective regulatory mechanism in a wide range of biological processes. In this study, we use single-molecule mechanical measurements to develop a full kinetic and energetic description of a highly conserved prol...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3992639/ https://ncbi.nlm.nih.gov/pubmed/24706888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319448111 |
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