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T cell receptor scanning of pMHC through complementary matching of receptor and ligand molecular flexibility()
Although conformational changes in TCRs and pMHC molecules often occur upon binding, their relationship to intrinsic flexibility and role in ligand selectivity are poorly understood. Here we used NMR to study TCR-pMHC binding, examining recognition of the QL9/H-2L(d) complex by the 2C TCR. Although...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3992338/ https://ncbi.nlm.nih.gov/pubmed/24523505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302953 |
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