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Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis
The p110δ subunit of class I(A) phosphoinositide 3-kinase modulates signaling in innate immune cells. We previously demonstrated that mice harboring a kinase-dead p110δ subunit (p110δ(KD)) develop spontaneous colitis. Macrophages contributed to the Th1/Th17 cytokine bias in p110δ(KD) mice through in...
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| Main Authors: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3992276/ https://ncbi.nlm.nih.gov/pubmed/24634494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301533 |
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