Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis

The p110δ subunit of class I(A) phosphoinositide 3-kinase modulates signaling in innate immune cells. We previously demonstrated that mice harboring a kinase-dead p110δ subunit (p110δ(KD)) develop spontaneous colitis. Macrophages contributed to the Th1/Th17 cytokine bias in p110δ(KD) mice through in...

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Bibliografski detalji
Glavni autori: Steinbach, Erin C., Kobayashi, Taku, Russo, Steven M., Sheikh, Shehzad Z., Gipson, Gregory R., Kennedy, Samantha T., Uno, Jennifer K., Mishima, Yoshiyuki, Borst, Luke B., Liu, Bo, Herfarth, Hans, Ting, Jenny P. Y., Sartor, R. Balfour, Plevy, Scott E.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992276/
https://ncbi.nlm.nih.gov/pubmed/24634494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301533
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