Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ

BACKGROUND AND AIMS: Innate immune responses are crucial for host defense against pathogens, but need to be tightly regulated to prevent chronic inflammation. Initial characterization of mice with a targeted inactivating mutation in the p110d subunit of phosphoinositide 3-kinase (PI3K p110δ(D910A/D9...

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Detalhes bibliográficos
Main Authors: Uno, Jennifer K., Rao, Kavitha N., Matsuoka, Katsuyoshi, Sheikh, Shehzad Z., Kobayashi, Taku, Li, Fengling, Steinbach, Erin C., Sepulveda, Antonia R., Vanhaesebroeck, Bart, Balfour Sartor, R, Plevy, Scott E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967619/
https://ncbi.nlm.nih.gov/pubmed/20637203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.07.008
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