Amphotericin forms an extramembranous and fungicidal sterol sponge

Amphotericin has remained the powerful but highly toxic last line of defense in treating life-threatening fungal infections in humans for over 50 years with minimal development of microbial resistance. Understanding how this small molecule kills yeast is thus critical for guiding development of deri...

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Bibliographische Detailangaben
Hauptverfasser: Anderson, Thomas M., Clay, Mary C., Cioffi, Alexander G., Diaz, Katrina A., Hisao, Grant S., Tuttle, Marcus D., Nieuwkoop, Andrew J., Comellas, Gemma, Maryum, Nashrah, Wang, Shu, Uno, Brice E., Wildeman, Erin L., Gonen, Tamir, Rienstra, Chad M., Burke, Martin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992202/
https://ncbi.nlm.nih.gov/pubmed/24681535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1496
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