Nanoparticles with Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice

BACKGROUND & AIMS: Nanoparticles have been explored as carriers of small interfering RNAs (siRNAs), and might developed to treat inflammatory bowel disease (IBD). Overexpression of CD98 on the surface of colonic epithelial cells and macrophages promotes development and progression of IBD. We dev...

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Hauptverfasser: Xiao, Bo, Laroui, Hamed, Viennois, Emilie, Ayyadurai, Saravanan, Charania, Moiz A., Zhang, Yuchen, Zhang, Zhan, Baker, Mark T., Zhang, Benyue, Gewirtz, Andrew T., Merlin, Didier
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992175/
https://ncbi.nlm.nih.gov/pubmed/24503126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.01.056
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