Nanoparticles with Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice

BACKGROUND & AIMS: Nanoparticles have been explored as carriers of small interfering RNAs (siRNAs), and might developed to treat inflammatory bowel disease (IBD). Overexpression of CD98 on the surface of colonic epithelial cells and macrophages promotes development and progression of IBD. We dev...

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Detalhes bibliográficos
Main Authors: Xiao, Bo, Laroui, Hamed, Viennois, Emilie, Ayyadurai, Saravanan, Charania, Moiz A., Zhang, Yuchen, Zhang, Zhan, Baker, Mark T., Zhang, Benyue, Gewirtz, Andrew T., Merlin, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992175/
https://ncbi.nlm.nih.gov/pubmed/24503126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.01.056
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