Nanoparticles with Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice

BACKGROUND & AIMS: Nanoparticles have been explored as carriers of small interfering RNAs (siRNAs), and might developed to treat inflammatory bowel disease (IBD). Overexpression of CD98 on the surface of colonic epithelial cells and macrophages promotes development and progression of IBD. We dev...

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Détails bibliographiques
Auteurs principaux: Xiao, Bo, Laroui, Hamed, Viennois, Emilie, Ayyadurai, Saravanan, Charania, Moiz A., Zhang, Yuchen, Zhang, Zhan, Baker, Mark T., Zhang, Benyue, Gewirtz, Andrew T., Merlin, Didier
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992175/
https://ncbi.nlm.nih.gov/pubmed/24503126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.01.056
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