A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

5′AMP-activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of mTORC1 pathway. However, whether AMPK activation itself is sufficient to block...

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Detalhes bibliográficos
Main Authors: Zadra, Giorgia, Photopoulos, Cornelia, Tyekucheva, Svitlana, Heidari, Pedram, Weng, Qing Ping, Fedele, Giuseppe, Liu, Hong, Scaglia, Natalia, Priolo, Carmen, Sicinska, Ewa, Mahmood, Umar, Signoretti, Sabina, Birnberg, Neal, Loda, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Backwell Publishing Ltd 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992078/
https://ncbi.nlm.nih.gov/pubmed/24497570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201302734
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