Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator()

The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which are class C G protein-coupled receptors (GPCRs). We determined the 2.8 Å resolution structure of the human mGlu(1) receptor seven-transmembrane (7TM) domain bound to a negativ...

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Main Authors: Wu, Huixian, Wang, Chong, Gregory, Karen J., Han, Gye Won, Cho, Hyekyung P., Xia, Yan, Niswender, Colleen M., Katritch, Vsevolod, Meiler, Jens, Cherezov, Vadim, Conn, P. Jeffrey, Stevens, Raymond C.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3991565/
https://ncbi.nlm.nih.gov/pubmed/24603153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1249489
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