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Increased numbers of pre-existing memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells()
Memory CD8 T cells acquire T(EM) properties following reinfection, and may reach terminally differentiated, senescent states (“Hayflick limit”) after multiple infections. The signals controlling this process are not well understood, but we found that the degree of 2(o) effector and memory CD8 T cell...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3991478/ https://ncbi.nlm.nih.gov/pubmed/21930973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002145 |
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