Inflammation Directs Memory Precursor and Short-Lived Effector CD8(+) T Cell Fates via the Graded Expression of T-bet Transcription Factor

As acute infections resolve, effector CD8 T cells differentiate into IL-7R(lo) short-lived effector cells (SLECs) and IL-7R(hi) memory precursor effector cells (MPECs) capable of generating long-lived memory CD8 T cells. Using another SLEC marker, KLRG1, we found that KLRG1(hi) effector cells began...

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Autores principales: Joshi, Nikhil S., Cui, Weiguo, Chandele, Anmol, Lee, Heung Kyu, Urso, David R., Hagman, James, Gapin, Laurent, Kaech, Susan M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034442/
https://ncbi.nlm.nih.gov/pubmed/17723218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.07.010
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