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Insulin-Like Growth Factor-I Regulates LH Release by Modulation of Kisspeptin and NMDA-Mediated Neurotransmission in Young and Middle-Aged Female Rats

This study investigated potential mechanisms by which age and IGF-I receptor (IGF-Ir) signaling in the neuroendocrine hypothalamus affect estradiol-positive feedback effects on GnRH neuronal activation and on kisspeptin and N-methyl-D-aspartate (NMDA)-induced LH release and on the abundance of NMDA...

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Detalhes bibliográficos
Main Authors: Neal-Perry, Genevieve, Yao, Dachun, Shu, Jun, Sun, Yan, Etgen, Anne M.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990844/
https://ncbi.nlm.nih.gov/pubmed/24617524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1682
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