In Vivo Ligands of MDA5 and RIG-I in Measles Virus-Infected Cells

RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune response against viral infections and detect patterns on viral RNA molecules that are typically absent from host RNA. Upon RNA binding, RLRs trigger a complex downstream signaling cascade resulting in the expres...

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Main Authors: Runge, Simon, Sparrer, Konstantin M. J., Lässig, Charlotte, Hembach, Katharina, Baum, Alina, García-Sastre, Adolfo, Söding, Johannes, Conzelmann, Karl-Klaus, Hopfner, Karl-Peter
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990713/
https://ncbi.nlm.nih.gov/pubmed/24743923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004081
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