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Effect of antimicrobial preservatives on partial protein unfolding and aggregation()
One-third of protein formulations are multi-dose. These require antimicrobial preservatives (APs); however, some APs have been shown to cause protein aggregation. Our previous work on a model protein cytochrome c indicated that partial protein unfolding, rather than complete unfolding, triggers aggr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3990441/ https://ncbi.nlm.nih.gov/pubmed/23169345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23362 |
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