CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility

We previously demonstrated that the Alzheimer's disease (AD) associated risk allele, rs3865444(C), results in a higher surface density of CD33 on monocytes. Here, we find alternative splicing of exon 2 to be the primary mechanism of the genetically driven differential expression of CD33 protein...

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Detalhes bibliográficos
Main Authors: Raj, Towfique, Ryan, Katie J., Replogle, Joseph M., Chibnik, Lori B., Rosenkrantz, Laura, Tang, Anna, Rothamel, Katie, Stranger, Barbara E., Bennett, David A., Evans, Denis A., De Jager, Philip L., Bradshaw, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990171/
https://ncbi.nlm.nih.gov/pubmed/24381305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt666
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