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CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility
We previously demonstrated that the Alzheimer's disease (AD) associated risk allele, rs3865444(C), results in a higher surface density of CD33 on monocytes. Here, we find alternative splicing of exon 2 to be the primary mechanism of the genetically driven differential expression of CD33 protein...
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| Główni autorzy: | , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Oxford University Press
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3990171/ https://ncbi.nlm.nih.gov/pubmed/24381305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt666 |
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