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An enhanced integrated stress response ameliorates mutant SOD1-induced ALS
Varied stresses to cells can lead to a repression in translation by triggering phosphorylation of eukaryotic translation initiator factor 2α (eIF2α), which is central to a process known as the integrated stress response (ISR). PKR-like ER-localized eIF2 kinase (PERK), one of the kinases that phospho...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3990163/ https://ncbi.nlm.nih.gov/pubmed/24368417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt658 |
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