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Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes
db/db mice are a model of obesity and diabetes due to their lack of functional leptin receptors, which leads to insulin resistance, elevated corticosterone levels, and persistent inflammation. Because stress-induced elevations in glucocorticoids sensitize microglia to immune challenges, we hypothesi...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989932/ https://ncbi.nlm.nih.gov/pubmed/24534266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2014.01.013 |
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