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S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding

The giant elastic protein titin is a determinant factor in how much blood fills the left ventricle during diastole, and thus in the etiology of heart disease. Titin has been identified as a target of S-glutathionylation, an end product of the nitric oxide signaling cascade that increases cardiac mus...

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Detalhes bibliográficos
Main Authors: Alegre-Cebollada, Jorge, Kosuri, Pallav, Giganti, David, Eckels, Edward, Rivas-Pardo, Jaime Andrés, Hamdani, Nazha, Warren, Chad M., Solaro, R. John, Linke, Wolfgang A., Fernández, Julio M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989842/
https://ncbi.nlm.nih.gov/pubmed/24630725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.056
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