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Trovafloxacin Potentiation of Lipopolysaccharide-Induced Tumor Necrosis Factor Release from RAW 264.7 Cells Requires Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase

Trovafloxacin (TVX) is a fluoroquinolone antibiotic known to cause idiosyncratic, drug-induced liver injury (IDILI) in humans. The mechanism underlying this toxicity remains unknown. Previously, an animal model of IDILI in mice revealed that TVX synergizes with inflammatory stress from bacterial lip...

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Main Authors: Poulsen, Kyle L., Albee, Ryan P., Ganey, Patricia E., Roth, Robert A.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989804/
https://ncbi.nlm.nih.gov/pubmed/24525298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.211276
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