Casein Kinase II Inhibition Reverses Pain Hypersensitivity and Potentiated Spinal N-Methyl-d-aspartate Receptor Activity Caused by Calcineurin Inhibitor

Clinically used calcineurin inhibitors, including tacrolimus (FK506) and cyclosporine A, can induce calcineurin inhibitor-induced pain syndrome (CIPS), which is characterized as severe pain and pain hypersensitivity. Increased synaptic N-methyl-d-aspartate receptor (NMDAR) activity in the spinal dor...

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Autori principali: Hu, Yi-Min, Chen, Shao-Rui, Chen, Hong, Pan, Hui-Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2014
Soggetti:
Neuropharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989802/
https://ncbi.nlm.nih.gov/pubmed/24610957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.212563
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