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Hyperhomocysteinemia attenuates angiogenesis through reduction of HIF-1α and PGC-1α levels in muscle fibers during hindlimb ischemia

Hyperhomocysteinemia (HHcy) is associated with elderly frailty, skeletal muscle injury and malfunction, reduced vascular integrity and function, and mortality. Although HHcy has been implicated in the impairment of angiogenesis after hindlimb ischemia in murine models, the underlying mechanisms are...

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מידע ביבליוגרפי
Main Authors: Veeranki, Sudhakar, Givvimani, Srikanth, Pushpakumar, Sathnur, Tyagi, Suresh C.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Physiological Society 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989752/
https://ncbi.nlm.nih.gov/pubmed/24585779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00003.2014
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