Hyperhomocysteinemia attenuates angiogenesis through reduction of HIF-1α and PGC-1α levels in muscle fibers during hindlimb ischemia

Hyperhomocysteinemia (HHcy) is associated with elderly frailty, skeletal muscle injury and malfunction, reduced vascular integrity and function, and mortality. Although HHcy has been implicated in the impairment of angiogenesis after hindlimb ischemia in murine models, the underlying mechanisms are...

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Detaylı Bibliyografya
Asıl Yazarlar: Veeranki, Sudhakar, Givvimani, Srikanth, Pushpakumar, Sathnur, Tyagi, Suresh C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2014
Konular:
Vascular Biology and Microcirculation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989752/
https://ncbi.nlm.nih.gov/pubmed/24585779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00003.2014
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