Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress

Increased osteopontin (OPN) expression associates with increased myocyte apoptosis and myocardial dysfunction. The objective of this study was to identify the receptor for OPN and get insight into the mechanism by which OPN induces cardiac myocyte apoptosis. Adult rat ventricular myocytes (ARVMs) an...

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Bibliografiske detaljer
Main Authors: Dalal, Suman, Zha, Qinqin, Daniels, Christopher R., Steagall, Rebecca J., Joyner, William L., Gadeau, Alain-Pierre, Singh, Mahipal, Singh, Krishna
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
Fag:
Signaling and Stress Response
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989747/
https://ncbi.nlm.nih.gov/pubmed/24531809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00954.2013
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