Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress

Increased osteopontin (OPN) expression associates with increased myocyte apoptosis and myocardial dysfunction. The objective of this study was to identify the receptor for OPN and get insight into the mechanism by which OPN induces cardiac myocyte apoptosis. Adult rat ventricular myocytes (ARVMs) an...

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Autores principales: Dalal, Suman, Zha, Qinqin, Daniels, Christopher R., Steagall, Rebecca J., Joyner, William L., Gadeau, Alain-Pierre, Singh, Mahipal, Singh, Krishna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2014
Materias:
Signaling and Stress Response
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989747/
https://ncbi.nlm.nih.gov/pubmed/24531809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00954.2013
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