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IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone
Chronic airway diseases are characterized by inflammation and mucus overproduction. The MUC5AC mucin gene is upregulated by the proinflammatory cytokine interleukin-1 β (IL-1β) via activation of cAMP response element-binding protein (CREB) in the NCI-H292 cancer cell line and nuclear factor-κB (NF-κ...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989721/ https://ncbi.nlm.nih.gov/pubmed/24487386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00347.2013 |
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