Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores

The spindle assembly checkpoint inhibits anaphase until all chromosomes have become attached to the mitotic spindle. A complex between the checkpoint proteins Mad1 and Mad2 provides a platform for Mad2:Mad2 dimerization at unattached kinetochores, which enables Mad2 to delay anaphase. Here, we show...

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Autores principales: Heinrich, Stephanie, Sewart, Katharina, Windecker, Hanna, Langegger, Maria, Schmidt, Nadine, Hustedt, Nicole, Hauf, Silke
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2014
Materias:
Scientific Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989695/
https://ncbi.nlm.nih.gov/pubmed/24477934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338114
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