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Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores
The spindle assembly checkpoint inhibits anaphase until all chromosomes have become attached to the mitotic spindle. A complex between the checkpoint proteins Mad1 and Mad2 provides a platform for Mad2:Mad2 dimerization at unattached kinetochores, which enables Mad2 to delay anaphase. Here, we show...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Publishing Ltd
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989695/ https://ncbi.nlm.nih.gov/pubmed/24477934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338114 |
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