Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2

Toll-like receptor 9 (TLR9) has a key role in the recognition of pathogen DNA in the context of infection and cellular DNA that is released from damaged cells. Pro-inflammatory TLR9 signalling pathways in immune cells have been well investigated, but we have recently discovered an alternative pathwa...

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Detalhes bibliográficos
Main Authors: Shintani, Yasunori, Drexler, Hannes CA, Kioka, Hidetaka, Terracciano, Cesare MN, Coppen, Steven R, Imamura, Hiromi, Akao, Masaharu, Nakai, Junichi, Wheeler, Ann P, Higo, Shuichiro, Nakayama, Hiroyuki, Takashima, Seiji, Yashiro, Kenta, Suzuki, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2014
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989675/
https://ncbi.nlm.nih.gov/pubmed/24610369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201337945
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